THE DETOX PROCESS

Clean Up & Thrive This Spring

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lean bodies run strong and last long.

Clean minds think clearly and live at peace.

We live in a toxic world. Over 85,000 chemicals are used by modern industry and many of those have never been tested for their effects on humans. In the Trump era what safety regulations existed are being rapidly buried.

It’s time to take matters into our own hands. Armed with the right information and guidance detoxifying can be easy and safe.

Conditions that can benefit from detox:

  • a wide range of mental health issues
  • stubborn weight problems
  • autoimmune disorders
  • stubborn neurological symptoms
  • many chronic pain issues
  • fatigue

The key to success is to adjust the Detox Process to your individual needs and responses. That’s why I’m making my highly-personalized program design and coaching services available to a limited number of clients this spring at a substantially discounted rate who want to turn back the clock and tune up their metabolisms.

Three Month Concierge Program

Your Own Personalized
Detox Protocol

$329

  • Initial Full Consult (60-90 Mins)
  • Detailed Consult Report w/Action Items
  • Next-Gen Functional Testing Explained
  • Fits the Detox to the Genes
  • Two 20-Minute Followup Consults w/Notes
  • Three Months Email and Txt Access
  • Clinical Lab Fees Not Included

To find out more, send an email

Or … schedule your free twenty minute consult.

Why Detox Matters

Life needed to protect itself from environmental toxins as soon as it first appeared. It wasn’t easy figuring out how to form cells and living things in earth’s early atmosphere, full of hydrogen sulfide and methane (think rotting eggs and feedlots.)

Billions of years later our bodies have highly evolved metabolic pathways to help us cope not only with poisons in the environment, but toxic substances created by our own cells as they:

  • generate energy,
  • defend us against enemy microbes,
  • and maintain chemical and electrical communication networks running the show.

But they weren’t designed for today’s challenges.

  • Food grown on farms protected by flood control projects in soil that therefore is never flooded and so never has its mineral content replenished.
  • Hundreds of years of technological innovation producing new and exponentially more toxic compounds.
  • Modern social structures with their constant stressors.

Our detox pathways help us cope with all of these every day, more or less. But when we rely on them too much so we can keep going through an ever-more toxic haze that’s often invisible to our eyes, our detox enzymes can have a hard time keeping up with their regular chores: helping our metabolisms run smooth, clean and strong. They can get stretched a little thin. Those smokestacks are still going, after all.

And then there’s the politics involved in doing something about all that. Different rant, still stressful: excellent example of external toxins creating internal toxicity as a whole nation is impacted by the stress.

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When we rely on them too much …
our detox enzymes can have
a hard time keeping up.

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When we rely on them too much …

our detox enzymes can have

a hard time keeping up.

How a Toxic Environment Feels

So what’s the impact of all this accumulating toxicity on our health?

We’ll see a little later in this series that some of us are genetically much more susceptible to toxicity than others.1,2,3,4,5 Our genes are as unique as our fingerprints, and not all of us are equally up to the toxic challenges life poses.6

One of the first organs affected is the brain. Two-percent of our body weight, the brain uses twenty percent of the body’s energy. So any issues with toxicity, growing inflammation or metabolic bottlenecks will often show up as dysfunctional behavior, cognitive or mood issues first.7,8

Toxins not only interfere with brain function directly, they also activate the innate immune system. This early-warning system can kick us into sickness behavior if it’s dealing with too much at once: generalized grumpiness and a tendency to self-isolate are classic signs.

Those of you who read between the lines may be tempted to draw far-reaching conclusions about the current state of our society from this connection. And you might not be wrong: classic Chinese medical texts are very clear that toxic people grow angry, depressed and tend to start fights instead of conversations.

Soon we might begin to see signs of frank disease as the physical body starts to break down. But the first signs tend to be distorted thinking and combative behavior.

Accumulating toxins (and the body’s immune responses to them) can impair energy production in our cells. As that happens we lose even more mental clarity and physical energy. A growing sense of unease envelops us and we can turn to self-medicating with alcohol, drugs or even the highly industrialized refined foods that set our inflammation in motion in the first place. Which of course just adds adds more inflammation.

When enough toxicity accumulates our cells lose their ability to efficiently burn fuel. We’ll feel tired, sluggish and out of sorts. Keep this up for a few years or decades and insulin resistance results. Then we start putting on weight. Dieting does no good; indeed it can make things worse as the body shuts down its metabolism, thinking that it needs to survive a period of starvation.

Much chronic disease … some would say most … then begins to appear, a direct result of prolonged low-to-medium-grade inflammation. Everything from cardiovascular disease9 to diabetes10 to cancer11,12 to autoimmune diseases to depression13,14 and dementia15 has been linked to this dynamic. Inflammation in a mother affects her unborn child’s health later in life.16,17,18

The slow damage chronic inflammation causes to the wet, wiggly soft machinery in our bodies is something like what would happen to our car engines if we never change the oil. Things wear out faster.

Ultimately inflammation oxides us. Think of the difference between the paint on a new car and the paint on an old pickup that’s been sitting in the backyard for a couple of decades. Think of the difference between a baby’s skin and the skin on an old smoker. These are largely the accumulated effects of oxidation.

But inflammation attacks more than the surface. Every tissue in every gland and organ of our bodies becomes slowly less competent, less flexible, less functional19,20 … the longer it’s chronically inflamed.

So understanding how all this works is key to having a long, healthy and productive existence while enjoying a good quality of life.

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An immune cell immobilizes and prepares to eat its prey: bacteria

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An immune cell immobilizes and prepares to eat its prey: bacteria

How Detox Works

It can help to understand a bit about how detoxification works.

To oversimplify just a bit, when our bodies encounter poisonous substances, their first order of business is to try to deal with the toxins immediately. Immune cells mobilize, attack the toxins, eat and isolate them, but then we’ve got toxic immune cell debris to deal with.

So mammalian bodies have evolved a two-step process for dealing with toxins.

  • In Phase I Detox, molecules known collectively as CYP450 enzymes bind with toxins in an effort to make them water-soluble, so they can be excreted by the kidneys. But these toxic intermediaries are half steps, and even more toxic. So that’s not enough.
  • Phase II enzymes then have grab those toxic intermediate molecules, rendering them harmless and making them even more water-soluble. Then they can be:
  • dumped in stool, urine or sweat, which some have now taken to calling Phase III.

So the name of the game, in our toxic modern world, is to make sure that all these detox systems have all the nutrients and they need to fuel their work and everything else they need to do their jobs.

Except that there’s some wrinkles:

  1. It’s relatively easy, if one is not careful, to push Phase I faster than Phase II can handle it. That leads to a buildup of those toxic intermediate molecules Phase I forms … many of which are more toxic than the original poisons. This can lead to all kinds of squirrely symptoms, known collectively (and somewhat disingenuously) as a “healing” or “detox” crisis.
  2. From this point of view, healing crises are poorly executed detoxes. The solution: we need to take our sweet time detoxing, especially if we’ve never done it before. And we need to support Phases III and II before Phase I if we’re going to do this gracefully.
  3. Depending on who you ask, something like 30-60% of the population has genetic SNPs21 (previously known as mutations) that impair some aspect of the detox process.

Why? You might ask. If genes that don’t help us adapt tend to disappear as the generations roll by, why would genes that impair detox still be around?

Interesting question; interesting enough that it deserves its own rant.

Stay tuned.

1. Kachiwala SJ, Harris SE, et al. “Genetic influences on oxidative stress and their association with normal cognitive ageing.Neurosci Lett. 2005 Sep 30;386(2):116-20.

2. Liu X, Kawamura Y, et al. “Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population.J Hum Genet. 2010 Mar;55(3):137-41.

3. Peerbooms OL, van Os J, et al. “Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?Brain Behav Immun. 2011 Nov;25(8):1530-43.

4. McKeown-Eyssen G, Baines C, et al. “Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR.Int J Epidemiol. 2004 Oct;33(5):971-8.

5. McFadden SA. “Phenotypic variation in xenobiotic metabolism and adverse environmental response: focus on sulfur-dependent detoxification pathways.Toxicology. 1996 Jul 17;111(1-3):43-65.

6. Korkina L, Scordo MG, et al. “The chemical defensive system in the pathobiology of idiopathic environment-associated diseases.Curr Drug Metab. 2009 Oct;10(8):914-31.

7. Shelton RC, Miller AH. “Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression.Prog Neurobiol. 2010 Aug;91(4):275-99.

8. Coccaro EF, Lee R, Gozal D. “Elevated Plasma Oxidative Stress Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans.Biol Psychiatry. 2016 Jan 15;79(2):127-35

9. Hamer M, Stamatakis E. “The accumulative effects of modifiable risk factors on inflammation and haemostasis.Brain Behav Immun. 2008 Oct;22(7):1041-3.

10. Capuron L, Su S, Miller AH, et al. “Depressive symptoms and metabolic syndrome: is inflammation the underlying link?Biol Psychiatry. 2008 Nov 15;64(10):896-900.

11. Weng MS, Chang JW, et al. “The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance.J Exp Clin Cancer Res. 2018; 37: 61.

12. Liu YU, Ding Y., et al “Functional macrophages and gastrointestinal disorders.World J Gastroenterol. 2018 Mar 21; 24(11): 1181–1195.

13. Shelton RC, Miller AH. “Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression.Prog Neurobiol. 2010 Aug;91(4):275-99.

14. Eisenberger NI, Inagaki TK, et al. “Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood.Brain Behav Immun. 2010 May;24(4):558-63.

15. Ayabe T, Ohya R, Kondo K, Ano Y. “Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline.Sci Rep. 2018; 8: 4760.

16. Bolton JL, Bilbo SD. “Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms.Dialogues Clin Neurosci. 2014 Sep;16(3):307-20.

17. Hanamsagar R, Bilbo SD. “Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development.J Steroid Biochem Mol Biol. 2016 Jun;160:127-33.

18. Bolton JL, Marinero S. “Gestational Exposure to Air Pollution Alters Cortical Volume, Microglial Morphology, and Microglia-Neuron Interactions in a Sex-Specific Manner.Front Synaptic Neurosci. 2017 May 31;9:10.

19. Theoharides TC, Konstantinidou AD. “Corticotropin-releasing hormone and the blood-brain-barrier.Front Biosci. 2007 Jan 1;12:1615-28.

20. Tatla S, Woodhead V. “The role of reactive oxygen species in triggering proliferation and IL-2 secretion in T cells.Free Radic Biol Med. 1999 Jan;26(1-2):14-24.

21. SNP = Single Nucleotide Polymorphism. Previously referred to as “mutations,” once it was recognized that genetic variances often bring benefits as well as costs, it was decided to retire the old term “mutation,” with its connotations of being a defect.